1. **Golden Gate Park**: Start your weekend with a leisurely stroll through this urban oasis. From the Japanese Tea Garden to the de Young Museum, there's plenty to explore.
2. **Alcatraz Island**: A visit to the infamous prison is a must. The audio tour provides a chilling yet fascinating glimpse into the lives of former inmates.
3. **Fisherman's Wharf**: Enjoy fresh seafood, street performances, and the iconic sea lions at Pier 39. It's touristy, but undeniably fun.
4. **Cable Car Ride**: Hop on one of the city's historic cable cars for a scenic ride. It's a great way to see the city and a quintessential San Francisco experience.
5. **Lombard Street**: Drive or walk down the "crookedest street in the world" for a unique photo opportunity.
6. **Golden Gate Bridge**: Walk or bike across this iconic bridge for stunning views of the city and the bay.
7. **Chinatown**: Explore the largest Chinatown outside of Asia. From dim sum to traditional markets, there's a rich cultural experience waiting for you.
8. **Union Square**: Shop till you drop at this premier shopping district. Whether you're into high-end boutiques or local shops, there's something for everyone.
9. **Twin Peaks**: For panoramic views of the city, head to Twin Peaks. It's especially magical at sunset.
10. **Palace of Fine Arts**: This stunning structure, originally built for the 1915 Panama-Pacific Exposition, is a great spot for a peaceful walk.
11. **Exploratorium**: A hands-on science museum that's perfect for both kids and adults. It's a great way to spend a few hours learning and having fun.
12. **California Academy of Sciences**: Located in Golden Gate Park, this museum houses an aquarium, planetarium, and natural history museum all under one roof.
13. **Mission District**: Explore the vibrant murals, eclectic shops, and delicious food options in this trendy neighborhood.
14. **SFMOMA**: The San Francisco Museum of Modern Art is a must-visit for art lovers. With a vast collection of contemporary art, it's a cultural highlight.
15. **Painted Ladies**: Take a stroll in Alamo Square to see the famous "Painted Ladies," a row of colorful Victorian houses.
16. **Coit Tower**: Climb to the top of this Art Deco tower for sweeping views of the city and the bay.
17. **Ferry Building Marketplace**: Enjoy a variety of artisanal foods and local products at this historic marketplace.
18. **Dolores Park**: A popular spot for locals to relax, picnic, and enjoy the sunshine. It's a great place to people-watch.
19. **San Francisco Zoo**: Spend a day with the animals at this family-friendly zoo. It's a great way to unwind and enjoy some wildlife.
20. **Nightlife**: End your weekend with a night out in the city. From jazz clubs to rooftop bars, San Francisco's nightlife is vibrant and diverse.
San Francisco is a city that truly has it all. Whether you're into history, culture, nature, or just having a good time, you'll find plenty to do over a long weekend. So pack your bags, bring your sense of adventure, and get ready to explore one of the most dynamic cities in the world.